Liebhoff A. Detection of Pathogenic Infections...Gene Expression Data 2021

Textbook in PDF format

For increasing the knowledge about small RNA an online platform was built in this thesis, homogenizing the analysis of sequencing data from over 4,000 samples collected in different laboratories worldwide from various organisms. Consequentially, tissue and disease specific biomarkers were detected and evidence was found for bacterial and viral infections of the sequenced tissues. This motivated the development of an algorithm for analyzing non-host RNA sequencing reads for detecting pathogenic abundance in the host. Focusing on neurological diseases, bacterial presence is suggested in brains of dementia patients. The platform and the algorithm can help scientists to add important leads to their own studies.
Biological background
Bioinformatics background
Computer science background
Small RNA Expression Atlas (SEA)
Biological discoveries through SEA
Pathogen detection in RNA-seq data
Path(ogen)s to disease