Paley E. Microbiome Metabolome Brain Vagus Nerve Circuit..Disease..Recovery 2023

Textbook in PDF format

Microbiome Metabolome Brain Vagus Nerve Circuit in Disease and Recovery focuses on the emerging hypothesis of a dysfunctional microbiome metabolome vagus nerve brain circuit in Alzheimer’s disease and associated diseases and medical conditions, including dementia, aging, COVID-19, autoimmune conditions, and inflammatory skin condition rosacea, which may increase the risk of other conditions. This book also discusses the vagus nerve-related conditions, including Arnold’s reflex, laryngopharyngeal reflux, duodenogastric reflux, gastroesophageal reflux, and related pulmonary diseases. The subjects covered in the book also address an important question of which one is more important for human health and intellectual abilities: the human genome or the human microbiome? The conceptual model of food and gut microbial tryptamine vagus nerve circuit is also presented in this book.
Introduction: Microbial metabolite interference of protein biosynthesis in neurodegenerative, neurodevelopmental, and other disorders; microbial metabolites hijacking vagus nerve
COVID-19: Scientific progress
Viral-bacterial interactions in diseases
Vagus nerve: Acid reflux, parietal cells, carpal tunnel syndrome, Alzheimer’s disease, COVID-19, stroke, cancer, and other diseases
Vagus nerve circuit: Microbiome—tryptophan metabolites—receptors and synapses
Glutamate and glutamate receptors in vagus nerve pathways and in Alzheimer’s disease
Aminoacyl tRNA synthetase multiple forms in autoimmune and infectious diseases
Crystalized aromatic l-amino acid decarboxylase from bacteria Micrococcus percitreus catalyzing decarboxylation of tryptophan and l-DOPA (Levodopa or 3,4-dihydroxy-l-phenylalanine)
Health effects of elevated CO2 levels, sparkling mineral water, seltzer carbonated water
Microbial antigens, allergies, and antibodies to microbial allergens: Significance of preexisting antibodies and stress for vaccination
Smell and taste identification deficits in disease
Microorganisms producing biogenic amines: From food to human body