Daolin T. Ferroptosis in Health and Disease 2ed 2023

Textbook in PDF format

This updated and expanded volume gives new insights on ferroptosis – an iron-dependent form of non-apoptotic cell death. The collection of chapters discusses the two major pathways through which ferroptosis can occur: the extrinsic or transporter-dependent pathway and the intrinsic or enzyme-regulated pathway.
Readers will gain an understanding of the multiple levels, on which this special cell death is regulated. Hence, the contributions will take a closer look at epigenetic, transcriptional, posttranscriptional and posttranslational layers. Among the described regulators and transcription factors are GPX4, ACSL4 and NFE2L2.
This edited volume collects reviews related to current knowledge on the integrated molecular machinery of ferroptosis, thereby also describing how dysregulated ferroptosis is involved in human diseases.
Preface
Lipid Metabolism and Homeostasis in Ferroptosis
Iron Metabolism and Ferroptosis
Targeting Epigenetic Regulation of Ferroptosis in Cancer Therapy
The Role of Autophagy in Ferroptosis
Heat Shock Proteins and HSF1 in Ferroptosis
The Ongoing Search for a Biomarker of Ferroptosis
p53 and Ferroptosis
Ferroptosis in Cardiovascular Disease
Understanding Ferroptosis from a Free Radical Perspective
The NRF2-anti-ferroptosis Axis in Health and Disease
Epigenetic Modification in Ferroptosis
Organelle-specific Mechanisms of Ferroptosis
Ferroptosis: A Promising Therapeutic Target for Cardiovascular Diseases
Ferroptosis in Central Nervous System Hypoxia-Ischemia
Involvement of Ferroptosis in Lupus Nephritis
Ferroptosis and Infectious Diseases
Selenium Metabolic Pathway in Ferroptotic Cell Death
Epigenetic and Posttranslational Regulation of Ferroptosis
Phospholipid Peroxidation in Health and Disease
PKCβII-ACSL4 Axis Triggers Ferroptosis and Its Potential Implication in Ferroptosis-Related Diseases
Cancer Treatment with Ferroptosis by a Combination of Iron Nanoparticles and Gene Therapy
Inhibitors of Oxytosis/Ferroptosis: A New Class of Therapeutics for Alzheimer´s Disease