Nance E. Engineering Biomaterials for Neural Applications 2022

Textbook in PDF format

This contributed volume explores the ways in which researchers engineer new biomaterials for the challenging problems of the peripheral and central nervous systems. These biomaterials are uniquely positioned for use in creating in vitro models of injury and disease, testing therapeutic treatments, understanding neural development, and mapping the multi-scalar environment of the brain. This book informs readers from biology, chemistry, materials science, engineering, and neuroscience on cutting edge research in engineering technologies, from fundamental material development through pre-clinical studies. The book also highlights target applications in three areas of research: (1) engineering neural models and materials, (2) probing biological underpinnings of neurological function and disease, and (3) designing therapeutic and diagnostic treatments for neurological disease.
Preface
Engineering Neural Models and Materials
Configurable Models of the Neurovascular Unit
Probing Biological Underpinnings of Neurological Function and Disease
Nano-Based Probes for the Brain Extracellular Environment
Engineered Materials for Probing and Perturbing Brain Chemistry
Microfluidic Devices for Analysis of Neuronal Development
Designing Therapeutic and Diagnostic Interventions for Neurological Disease
Bioresponsive Nanomaterials for CNS Disease
Polymer-Mediated Delivery of CRISPR-Cas9 Genome-Editing Therapeutics for CNS Disease
Multifunctional Polymeric Nanocarriers for Targeted Brain Delivery
Theranostic Nanomaterials for Brain Injury
Index