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Beebe S. Ultrashort Electric Pulse Effects in Biology and Medicine 2021

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Total size: 19.11 MB
Added: 2025-03-10 23:38:54

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Info Hash: E875B6DA8FD92108ABA35E84FFD55EE01DED3EAD
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Textbook in PDF format This book presents an overview of the current state of research on ultrashort electric field pulses of high intensity and their use in biology and medicine. It examines in detail the most recent and exciting advances in how nanosecond and picosecond electric pulse research has grown and expanded into new areas of biology and medicine. Further, the book specifically focuses on electric pulses in the time domain, on intracellular effects as opposed to plasma membrane electroporation, and highlights the biological and medical applications of these unique pulse effects. Since the authors were initial innovators exploring nanosecond and picosecond pulses, their unique perspectives foreshadowed directions the research took, expanding into new areas that they continue to investigate today. Front Matter Introduction Effects of usEPs on Plasma Membranes—Pores, Channels, and Repair Simulations of Membrane Effects of Cells After Exposure to Ultrashort Pulses Comparison Between Monopolar and Bipolar Pulses for Effective Nanoporation usEP Effects on the Endoplasmic Reticulum (ER) Intra-cellular Calcium Release Dynamics Due to Nanosecond Electric Pulsing Effects of usEPs on DNA, Nuclear, and Subnuclear Compartments Mitochondria as usEP Sensors usEP Induce Regulated Cell Death Mechanisms Model Rate Equation Evaluation of an Extrinsic Apoptotic Pathway Thermal Effects in Bioelectrics Synergy Between Electric Pulse and Thermal Effects Synergy Between Electric Pulsing and Shock Waves for Cell Poration Probing Potential for Cellular Stimulation by Time-Varying Magnetic Fields Pulsed Power Generators Pulse Delivery and Exposure Systems Pulse Voltage Measurement usEPs in Pre-clinical Cancer Treatment usEPs as a Possible Immunotherapy