Espay A. Precision Medicine in Neurodegenerative Disorders. Part II 2023

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Espay A. Precision Medicine in Neurodegenerative Disorders. Part II 2023

Textbook in PDF format Foreword In Memoriam–Michael Parkinson Preface Contributors Basic science development Role of rodent models in advancing precision medicine for Parkinson's disease The allure and pitfalls of the prion-like aggregation in neurodegeneration The shift to a proteinopenia paradigm in neurodegeneration Disease mechanisms as subtypes: Lysosomal dysfunction in the endolysosomal Parkinson's disease subtype Disease mechanisms as Subtypes: Mitochondrial and bioenergetic dysfunction Disease mechanisms as subtypes: Immune dysfunction in Parkinson's disease Disease mechanisms as subtypes: Inflammation in Parkinson disease and related disorders Disease mechanisms as subtypes: Microbiome LRRK2: Genetic mechanisms vs genetic subtypes Genetic mechanism vs genetic subtypes: The example of GBA Subtyping monogenic disorders: Huntington disease Clinical trials and therapeutic approaches Disease-modifying vs symptomatic treatments: Splitting over lumping Restorative cell and gene therapies for Parkinson's disease The promise and challenges of extracellular vesicles in the diagnosis of neurodegenerative diseases Therapeutic potential of extracellular vesicles in neurodegenerative disorders Lessons from antiamyloid-β immunotherapies in Alzheimer's disease Lessons from immunotherapies in multiple sclerosis Adaptive clinical trials and master protocols Role of novel endpoints and evaluations of response in Parkinson disease Leveraging the regulatory framework to facilitate drug development in Parkinson's disease Index