Wang Z. The Chemistry and Biology of Beta-Lactams 2023

Textbook in PDF format

This new volume provides the most updated information about beta-lactams relating to both the pharmaceutical industry and synthetic chemistry. It provides the antibiotic activities as well as chemical reactivities of beta-lactams, which are important because they are commonly applied as antibiotics in the treatment of bacterial infections. The volume provides comprehensive coverage of most of the known beta-lactam antibiotics with both structural and biological information, antibiotic mechanisms, self-defense mechanisms of bacteria, nearly all known synthetic methods for the preparation of beta-lactams, and possible reactions in which beta-lactams can participate.
Key features:
Provides the most comprehensive collection of beta-lactam antibiotics (up to 269 molecules) with chemical structures, CAS number, IUPAC names and associated biological activities attached.
Offers a comprehensive and detailed collection of beta-lactamase databases.
Explains the self-defense mechanisms of bacteria for surviving, including the formation of biofilm and conversion into L-form and secretion of beta-lactamase to deactivate the beta-lactam antibiotics.
Provides a comprehensive survey on the synthetic methods to make beta-lactams.
Gives all of the possible reactions involving beta-lactams as the starting materials.
Surveys over 1000 research works and includes all available DOI information.
The volume is a valuable resource on the antibiotic activities as well as chemical reactivities of beta-lactams for researchers and scientists, faculty, and advanced students, as well as for industry professionals working in medicinal and pharmaceutical chemistry, organic chemistry, organic synthesis, heterocycles, proteins and peptides.
β-Lactams and Antibiotics
Antimicrobial Activity of β-Lactams and Bacterial Resistance
Synthetic Methods of β-Lactams
Reactions of β-Lactams