Yi W. Chemistry and Biology of O-GlcNAcylation 2024

Textbook in PDF format

O-linked N-acetylglucosamine (O-GlcNAc) is a prevalent post-translational modification of numerous intracellular proteins. This modification has recently emerged as a key regulator of various important biological processes, including gene transcription, stress response, metabolic homeostasis, and immune regulation. Given the critical role of O-GlcNAc in normal physiology, increasing evidence has now demonstrated that deregulation of O-GlcNAc is closely associated with the development and progression of various diseases, including neurodegeneration, cardiovascular disease, and cancer. This book provides a comprehensive overview of the current progress and understanding of this modification in biology, and likely provides new research directions in the future.
Chemical Tools for Decoding the Functions of O-GlcNAcylation
Profiling O-GlcNAcylation with Mass Spectrometry
O-GlcNAcylation and Cell Metabolism
O-GlcNAcylation in Transcriptional Regulation and Epigenetics
O-GlcNAc and Signal Transduction in Cancer
O-GlcNAcylation and Stem Cells
O-GlcNAcylation and Immune Regulation
O-GlcNAcylation in Neuronal Development, Neurodegeneration, and Neurological Disorders